Abstract
Purpose: Today, the gold standard way to diagnosis of prostat cancer is ultrasound (US)-guided biopsy. General literature suggests 12 core samples, although lower core samples are sometimes done for diagnosis. In this study we researched to find effect of sampling number on gleason score of prostate biopsy and radical prostatectomy.
Materials and Methods: In our clinic, 203 patients who have diagnosed prostate ade-nocarsinom by transrectal ultrasound guided prostate biopsy because of suspicious fo prostat cancer between march 2011 and february 2016 were included to our study. Patients were divi-ded into two groups according to the number of samples. The first group named extended bi-opsy group includes 12 and above samples ta-ken patients and the second group named limi-ted biopy group includes less than 12 samples. Both the group’s relations with the biopsy and prostatectomy gleason scores were evaluated individually and were investigated statistically significancy.
Results: Extended biopsy group consisted of 94 patients, in this group the mean age was calculated 65 years, mean PSA level was 7,6 ng/mL and mean positive sample/ overall sample was 4,4/12,4. limited biopsy group consisted of 109 patients, in this group the mean age was calculated 61,9 years, mean PSA level was 10,5 ng/mL and mean positive sample/ overall sample was 3,6/10,2. The-re was no statistically significant difference between both age groups and in PSA levels. When looking at all patients; in 120 patients of all (59.1%) were the same as the final Gleason score and biopsy Gleason score, in 64 cases (31.6%) the final score higher, in 19 cases (9.3%) have less than the final Gleason score. 59 patients(% 62.8) of extended group had the same score, 23 patients(% 24.5) had higher score and 12 patients (% 12.7) had less final gleason score. 61 patients(% 56) of li-mited group had the same score, 41 patients(% 37,6) had higher score and 7 patients (% 6,4) had less final gleason score.
Conclusions: Extended prostate needle biopsy improves the pro-bability of detection of prostat canser and has more consistent Glea-son scores than limited biopsy. Consistency with the final pathological gleason score on extended biopsy was found more statictical signifi-cancy. The increase or decrease in final gleason score was more often seen on biopsy that was taken less sample and so It makes questionab-le the accuracy of the choice of treatment.
Keywords: Prostate Cancer; Needle biopsy; Gleason score, Radi-cal Prostatectomy
Abstract
Abstract
Purpose: Today, the gold standard way to diagnosis of prostat cancer is ultrasound (US)-guided biopsy. General literature suggests 12 core samples, although lower core samples are sometimes done for diagnosis. In this study we researched to find effect of sampling number on gleason score of prostate biopsy and radical prostatectomy.
Materials and Methods: In our clinic, 203 patients who have diagnosed prostate ade-nocarsinom by transrectal ultrasound guided prostate biopsy because of suspicious fo prostat cancer between march 2011 and february 2016 were included to our study. Patients were divi-ded into two groups according to the number of samples. The first group named extended bi-opsy group includes 12 and above samples ta-ken patients and the second group named limi-ted biopy group includes less than 12 samples. Both the group’s relations with the biopsy and prostatectomy gleason scores were evaluated individually and were investigated statistically significancy.
Results: Extended biopsy group consisted of 94 patients, in this group the mean age was calculated 65 years, mean PSA level was 7,6 ng/mL and mean positive sample/ overall sample was 4,4/12,4. limited biopsy group consisted of 109 patients, in this group the mean age was calculated 61,9 years, mean PSA level was 10,5 ng/mL and mean positive sample/ overall sample was 3,6/10,2. The-re was no statistically significant difference between both age groups and in PSA levels. When looking at all patients; in 120 patients of all (59.1%) were the same as the final Gleason score and biopsy Gleason score, in 64 cases (31.6%) the final score higher, in 19 cases (9.3%) have less than the final Gleason score. 59 patients(% 62.8) of extended group had the same score, 23 patients(% 24.5) had higher score and 12 patients (% 12.7) had less final gleason score. 61 patients(% 56) of li-mited group had the same score, 41 patients(% 37,6) had higher score and 7 patients (% 6,4) had less final gleason score.
Conclusions: Extended prostate needle biopsy improves the pro-bability of detection of prostat canser and has more consistent Glea-son scores than limited biopsy. Consistency with the final pathological gleason score on extended biopsy was found more statictical signifi-cancy. The increase or decrease in final gleason score was more often seen on biopsy that was taken less sample and so It makes questionab-le the accuracy of the choice of treatment.
Keywords: Prostate Cancer; Needle biopsy; Gleason score, Radi-cal Prostatectomy