Interstitial pneumonia: A rare complication after intravesical Mitomycin-C treatment for bladder tumor

Abstract

Sixty six years-old male patient, who un-derwent transurethral resection of bladder tumor and consequent intravesical Mitomy-cin-C chemotherapy, developed interstitial pneumonia. Forty mg intravesical Mitomy-cin-C was instillated weekly. Four days after the third instillation, the patient presented to emergency service with the complaint of progressive dyspnea. High resolution tho-rax tomography demonstrated ground glass opacity in the right upper and bilateral lower lobes, bilateral pleural effusion and interlob-ular septal thickening. Infection and collagen vascular disease were excluded. Symptomatic and radiological improvement achieved with discontinuation of intravesical Mitomycin-C and initiation of prednisolone treatment. In-travesical Mitomycin-C may cause rare sys-temic side effects like interstitial pneumonia. Keywords: Mitomycin; Lung Diseases, Interstitial; Pneumonia; Urinary Bladder Neoplasms

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