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Case Report

Primitive Neuroectodermal Tumor of Kidney: success of neoadjuvant chemotherapy in an unresectable tumor?


1 İzmir Katip Çelebi University, Faculty of Medicine, Urology Department, İzmir

2 İzmir Atatürk Education and Research hospital, Urology Department, İzmir


DOI :
2016; 11 (3): 42-45

Abstract

Objective: Primitive neuroectodermal tu-mors (PNET) of the kidney are very rare tu-mors with aggressive behavior. They usually are associated with poor prognosis.

Case: A 26-year old male patient presented to our clinic with right flank pain, microscopic hematuria and moderate-heavy nausea com-plaints. CT imaging studies showed a tumor with 17x13x18 cm dimensions. A mass excision was not possible caused by tumor spread to liv-er surface and duodenum and the tumor could not be separated from these surfaces. The op-eration was finished with an excisional biopsy.

The patient received 7 cycles of alternating IE/VAC chemotherapy sessions. At 5th month of follow-up, PET-CT scans showed that the tumor was regressed to 8x6x7 cm dimensions. Following this outcome, radical nephrectomy was performed without risking any other or-gans.

Conclusion: Neoadjuvant chemotherapy can be employed prior to radical nephrectomy in such cases in order to radically/efficiently/drastically reduce the tumor mass

Key Words: neuroectodermal tumor, kid-ney, neoadjuvant chemotherapy


Abstract

Objective: Primitive neuroectodermal tu-mors (PNET) of the kidney are very rare tu-mors with aggressive behavior. They usually are associated with poor prognosis.

Case: A 26-year old male patient presented to our clinic with right flank pain, microscopic hematuria and moderate-heavy nausea com-plaints. CT imaging studies showed a tumor with 17x13x18 cm dimensions. A mass excision was not possible caused by tumor spread to liv-er surface and duodenum and the tumor could not be separated from these surfaces. The op-eration was finished with an excisional biopsy.

The patient received 7 cycles of alternating IE/VAC chemotherapy sessions. At 5th month of follow-up, PET-CT scans showed that the tumor was regressed to 8x6x7 cm dimensions. Following this outcome, radical nephrectomy was performed without risking any other or-gans.

Conclusion: Neoadjuvant chemotherapy can be employed prior to radical nephrectomy in such cases in order to radically/efficiently/drastically reduce the tumor mass

Key Words: neuroectodermal tumor, kid-ney, neoadjuvant chemotherapy