Objective: In this study, we investigated relationship between the positive core percentage and gleason score with perineural invasion (PNI) in patients who underwent transrectal ultrasonography (TRUSG) guided prostate biopsy because of high prostate specific antigen (PSA) values and abnormal digital rectal examination.
Materials and Methods: A total of 1135 patients underwent 10-qu-adrant TRUSG guide prostate biopsy because of high PSA values and abnormal digital rectal examination in our clinic between 2004-2011. Prostate adenocarcinoma was detected in 274 patients (24.14%). Peri-neural invasion was demonstrated in 46(16.78%) of prostate carcinoma cases. Cases with and without PNI were compared in terms of age, to-tal PSA, prostate volume, PSA density, gleason score, positive core per-centage and rectal examination. Patients were divided into 2 groups of total gleason score ≤6 and total gleason score >6, also positive core per-centages were divided into 2 groups (≤33% and > 33%) and these gro-ups were compared in terms of perineural invasion.
Results: The mean age was 69.60 ± 6.56 in patients with gleason score ≤6 and 70.68 ± 8.34 in patients with gleason score > 6 (p=0.153). The mean PSA level was 12.10 ± 4.57 mg/ dl in patients with gleason score ≤ 6 and 13.11 ± 4.53 in patients with gleason score >6 (p=0.652). The rate of metastasis on bone scintigraphy was 31.25% in total, 6.6% in with gleason score ≤ 6 and 46.6% in patients with gleason score >6 (p<0.001). There was no singnificant difference in terms of age and to-tal PSA between the both two groups, however metastasis on bone scin-tigraphy was significantly higher in the patient with gleason score>6 (p<0.001).
Conclusion: Gleason score and positive cor percentage are indica-tors of poor prognosis in patients with prostate cancer. In this study, we observed a strong correlation between the gleason score and positif core percentage with perineural invasion. We believe that perineural invasi-on is an important prognostic factor to determine treatment options in patients with prostate cancer.
Key Words: Prostate biopsy, Perineural invasion, Gleason score
Abstract
Objective: In this study, we investigated relationship between the positive core percentage and gleason score with perineural invasion (PNI) in patients who underwent transrectal ultrasonography (TRUSG) guided prostate biopsy because of high prostate specific antigen (PSA) values and abnormal digital rectal examination.
Materials and Methods: A total of 1135 patients underwent 10-qu-adrant TRUSG guide prostate biopsy because of high PSA values and abnormal digital rectal examination in our clinic between 2004-2011. Prostate adenocarcinoma was detected in 274 patients (24.14%). Peri-neural invasion was demonstrated in 46(16.78%) of prostate carcinoma cases. Cases with and without PNI were compared in terms of age, to-tal PSA, prostate volume, PSA density, gleason score, positive core per-centage and rectal examination. Patients were divided into 2 groups of total gleason score ≤6 and total gleason score >6, also positive core per-centages were divided into 2 groups (≤33% and > 33%) and these gro-ups were compared in terms of perineural invasion.
Results: The mean age was 69.60 ± 6.56 in patients with gleason score ≤6 and 70.68 ± 8.34 in patients with gleason score > 6 (p=0.153). The mean PSA level was 12.10 ± 4.57 mg/ dl in patients with gleason score ≤ 6 and 13.11 ± 4.53 in patients with gleason score >6 (p=0.652). The rate of metastasis on bone scintigraphy was 31.25% in total, 6.6% in with gleason score ≤ 6 and 46.6% in patients with gleason score >6 (p<0.001). There was no singnificant difference in terms of age and to-tal PSA between the both two groups, however metastasis on bone scin-tigraphy was significantly higher in the patient with gleason score>6 (p<0.001).
Conclusion: Gleason score and positive cor percentage are indica-tors of poor prognosis in patients with prostate cancer. In this study, we observed a strong correlation between the gleason score and positif core percentage with perineural invasion. We believe that perineural invasi-on is an important prognostic factor to determine treatment options in patients with prostate cancer.
Key Words: Prostate biopsy, Perineural invasion, Gleason score