Objective: Transrectal ultrasound-guided prostate needle biopsy (TRUSPB) frequency is increased due to wide spread use of prostate spe-cific antigen (psa) for diagnosis of prostate can-cer. Without doubt urosepsis complications is the most lethal complication. In this study we evalu-ated incidence and results of sepsis and cases of the causative pathogen with antibiotic resistance after transrectal ultrasound guided prostate need-le biopsy.
Patients and Methods: Between 2010 and 2014 years 2350 patients undergoing biopsy for suspected prostate cancer were screened retros-pectively. All patients recieved two doses oral 500mg ciprofloxacin one day before the biopsy and rectal enema were given 6 hours pre-biopsy. Transrectal 2% lidocaine was injected for local anesthesia. Biopsies were performed using 18 gauge automated spring-loaded biopsy gun with transrectal ultrasound guided.
Results: Total 2224 patients were included in the study. 16 cases of sepsis was observed. Blood culture was positive in three of the patients and urine culture was positive in five of the patients. Patients was treated by infection specialist with broad-spectrum antibiotics listed in Table 1. The average hospitalization time was 7-10 days. Cip-rofloxacin resistance was detected in all patient that have positive blood and/or urine culture.
Conclusion: In our clinic, the frequency of sepsis was found to be %0,7 and there was no mortality. According to these results, ciprofloxa-cin prophylaxis is safe and effective in TRUSPB. Urosepsis which is the most feared complication is rarely seen and it can be treated with appropri-ate antibiotics.
Key Words: Prostate cancer, prostate biopsy, sepsis, antibiotic prophylaxis
Abstract
Objective: Transrectal ultrasound-guided prostate needle biopsy (TRUSPB) frequency is increased due to wide spread use of prostate spe-cific antigen (psa) for diagnosis of prostate can-cer. Without doubt urosepsis complications is the most lethal complication. In this study we evalu-ated incidence and results of sepsis and cases of the causative pathogen with antibiotic resistance after transrectal ultrasound guided prostate need-le biopsy.
Patients and Methods: Between 2010 and 2014 years 2350 patients undergoing biopsy for suspected prostate cancer were screened retros-pectively. All patients recieved two doses oral 500mg ciprofloxacin one day before the biopsy and rectal enema were given 6 hours pre-biopsy. Transrectal 2% lidocaine was injected for local anesthesia. Biopsies were performed using 18 gauge automated spring-loaded biopsy gun with transrectal ultrasound guided.
Results: Total 2224 patients were included in the study. 16 cases of sepsis was observed. Blood culture was positive in three of the patients and urine culture was positive in five of the patients. Patients was treated by infection specialist with broad-spectrum antibiotics listed in Table 1. The average hospitalization time was 7-10 days. Cip-rofloxacin resistance was detected in all patient that have positive blood and/or urine culture.
Conclusion: In our clinic, the frequency of sepsis was found to be %0,7 and there was no mortality. According to these results, ciprofloxa-cin prophylaxis is safe and effective in TRUSPB. Urosepsis which is the most feared complication is rarely seen and it can be treated with appropri-ate antibiotics.
Key Words: Prostate cancer, prostate biopsy, sepsis, antibiotic prophylaxis