Objective: To evaluate the effect of age on recurrence and progression in patients with pri- mary and non-muscle invasive bladder cancer (NMIBC).
Material and Methods: The records of pa- tients who underwent transurethral bladder tumor resection (TUR-BT) for primary bladder tumor between 2005-2010 were retrospectively reviewed. Patients who had NMIBC after the first TUR-BT and without extra-bladder involvement were in- cluded in the study. The patients were grouped in terms of age (under 60 years, 60-70 years, over 70 years), sex, tumor size (below and above 3 cm); the number of tumors (between 1, 2-7 and> 7); stage (Ta and T1) and grade (G1, G2 and G3).
Results: A total of 316 patients were included in the study. Recurrence was seen in 226 (71.5%) and progression 71 patients (22.5%). Univariate analysis showed that age (> 70), tumor number (> 1), size (> 3 cm), stage (T1) and grade (G3) are effective in the development of recurrence and progression. Kaplan-Meier analysis showed that there was a significant difference between the age groups in terms of time to recurrence (p = 0.001), as age increased the probability of recurrence increased and time to recurrence decreased. There was a significant difference be- tween the groups in the progression analysis and that the risk of progression increased with age and the time to progression decreased (p = 0.004). Conclusions: We found that the proba- bility of recurrence and progression was sig- nificantly increased with age, especially over 70 years of age, in patients with NMIBC.
Keywords: Bladder cancer, non-muscle in- vazive, advanced age, progression, recurrence.
Abstract
Objective: To evaluate the effect of age on recurrence and progression in patients with pri- mary and non-muscle invasive bladder cancer (NMIBC).
Material and Methods: The records of pa- tients who underwent transurethral bladder tumor resection (TUR-BT) for primary bladder tumor between 2005-2010 were retrospectively reviewed. Patients who had NMIBC after the first TUR-BT and without extra-bladder involvement were in- cluded in the study. The patients were grouped in terms of age (under 60 years, 60-70 years, over 70 years), sex, tumor size (below and above 3 cm); the number of tumors (between 1, 2-7 and> 7); stage (Ta and T1) and grade (G1, G2 and G3).
Results: A total of 316 patients were included in the study. Recurrence was seen in 226 (71.5%) and progression 71 patients (22.5%). Univariate analysis showed that age (> 70), tumor number (> 1), size (> 3 cm), stage (T1) and grade (G3) are effective in the development of recurrence and progression. Kaplan-Meier analysis showed that there was a significant difference between the age groups in terms of time to recurrence (p = 0.001), as age increased the probability of recurrence increased and time to recurrence decreased. There was a significant difference be- tween the groups in the progression analysis and that the risk of progression increased with age and the time to progression decreased (p = 0.004). Conclusions: We found that the proba- bility of recurrence and progression was sig- nificantly increased with age, especially over 70 years of age, in patients with NMIBC.
Keywords: Bladder cancer, non-muscle in- vazive, advanced age, progression, recurrence.