Objective: The aim of this study was to evaluate the incidence, histopathological re-sults and oncologic outcome of patients who underwent radical cystoprostatectomy for bladder tumors and detected incidental pros-tate adenocarcinoma.
Materials-Methods: 190 patients who were not proved to have preoperative prostate cancer and underwent radical cystoprosta-tectomy and diagnosed as prostate cancer as a second cancer between January 2010 and December 2017 were included in this study. Patients were randomly divided into two groups those with and without incidentally prostate cancer. Both groups were compared in terms of age, preoperative PSA value, body mass index, stage and grade of bladder tumor, accompanying of carcinoma in situ, surgical margin positivity, lymph node involvement and overall survival retrospectively.
Results: The clinical and the histopatho-logical features of the patients were summa-rized on Table 1 and Table 2. Fourty-three of the 190 patients (22.6 %) were detected pros-tate adenocarcinoma by the histopathological evaluation. The mean preoperative PSA level was 5.38 ng / ml in patients who had pros-tate cancer and the mean PSA value in the group without prostate cancer was 2.72 ng/ml (p=0,015). The mean duration of follow-up was 26 (3-74) months. The biochemical recur-rence was detected at 5 (11.6%) patients dur- ing the follow-up. When the two groups were evaluated for 5-year survival rates that was 61% for patients with prostate cancer and 53% for patients without prostate cancer (p=0.471).
Conclusion: The incidence of incidental prostate cancer after radical cystoprostatectomy increases with age but does not affect the prognosis of patients. In particular, the patients with locally advanced prostate cancer were needed to follow carefully and regularly.
Keywords: Prostate Cancer, Bladder Cancer, Radical Cystec-tomy
Abstract
Objective: The aim of this study was to evaluate the incidence, histopathological re-sults and oncologic outcome of patients who underwent radical cystoprostatectomy for bladder tumors and detected incidental pros-tate adenocarcinoma.
Materials-Methods: 190 patients who were not proved to have preoperative prostate cancer and underwent radical cystoprosta-tectomy and diagnosed as prostate cancer as a second cancer between January 2010 and December 2017 were included in this study. Patients were randomly divided into two groups those with and without incidentally prostate cancer. Both groups were compared in terms of age, preoperative PSA value, body mass index, stage and grade of bladder tumor, accompanying of carcinoma in situ, surgical margin positivity, lymph node involvement and overall survival retrospectively.
Results: The clinical and the histopatho-logical features of the patients were summa-rized on Table 1 and Table 2. Fourty-three of the 190 patients (22.6 %) were detected pros-tate adenocarcinoma by the histopathological evaluation. The mean preoperative PSA level was 5.38 ng / ml in patients who had pros-tate cancer and the mean PSA value in the group without prostate cancer was 2.72 ng/ml (p=0,015). The mean duration of follow-up was 26 (3-74) months. The biochemical recur-rence was detected at 5 (11.6%) patients dur- ing the follow-up. When the two groups were evaluated for 5-year survival rates that was 61% for patients with prostate cancer and 53% for patients without prostate cancer (p=0.471).
Conclusion: The incidence of incidental prostate cancer after radical cystoprostatectomy increases with age but does not affect the prognosis of patients. In particular, the patients with locally advanced prostate cancer were needed to follow carefully and regularly.
Keywords: Prostate Cancer, Bladder Cancer, Radical Cystec-tomy