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Original Research

Use of B-2 Microglobulin and Pentraxin as an Inflammatory Marker in the Early Post-Renal Transplantation Period


1    Sağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Üroloji Anabilim Dalı, İstanbul, Türkiye
2    Sağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Nefroloji Kliniği, İstanbul, Türkiye 
3     Muş Devlet Hastanesi, Muş
4     Sağlık Bilimleri Üniversitesi, Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Biyokimya, İstanbul
 


DOI : 10.33719/yud.643442
New J Urol. 2020; 15-(2): 121-126

Abstract

Objective: CRP was the most commonly used marker of inflammation in renal transplant reci- pients in chronic renal disease, and renal functi- ons were monitored with creatinine levels. In this study, we recorded the early course of B2 microg- lobulin and pentraxin levels as inflammatory mar- kers in renal transplant patients and aimed to de- termine its usefulness as markers of inflammation. Materials and Methods: This is a prospective observation study of 23 adult patients who un- derwent renal transplantation from living donors between January and June 2017. Demographic characteristics, blood samples, biochemical para- meters and inflammation markers were studied on the first day, 3rd day, 7th day and 30th day after transplantation.

Results: 18 (78%) of the 23 patients included in our study were in the pre-transplant dialysis program and 5 (22%) received preemptive dialysis. There were significant decreases in B2 microglo- bulin levels on the first postoperative day on the 3rd day and 7th day (p <0.05), but no significant difference was found between the 1st week and the first month (p> 0.05). Creatinine levels decreased significantly on the third day compared to the first day. There was a significant positive correla- tion between B2 microglobulin and creatinine at postoperative day 0, day 3, day 7 and month 1 (p <0.05). Pentraxine and CRP levels increased signi- ficantly on the third day compared to the first day, then decreased significantly on the 7th day and the first month. (P <0.05) However, there was no significant correlation between pentraxin changes and CRP changes.

Conclusion: Early detection of inflammation in renal transplant recipients is important for the risk of graft rejection. B2 microglobu- lin and pentraxin levels may be used as new markers for graft rejec- tion and renal function evaluation, but randomized controlled trials with larger patient numbers are needed.

Keywords:: B2-microglobulin, inflammation, pentraxin, transplantation
 


Abstract

Objective: CRP was the most commonly used marker of inflammation in renal transplant reci- pients in chronic renal disease, and renal functi- ons were monitored with creatinine levels. In this study, we recorded the early course of B2 microg- lobulin and pentraxin levels as inflammatory mar- kers in renal transplant patients and aimed to de- termine its usefulness as markers of inflammation. Materials and Methods: This is a prospective observation study of 23 adult patients who un- derwent renal transplantation from living donors between January and June 2017. Demographic characteristics, blood samples, biochemical para- meters and inflammation markers were studied on the first day, 3rd day, 7th day and 30th day after transplantation.

Results: 18 (78%) of the 23 patients included in our study were in the pre-transplant dialysis program and 5 (22%) received preemptive dialysis. There were significant decreases in B2 microglo- bulin levels on the first postoperative day on the 3rd day and 7th day (p <0.05), but no significant difference was found between the 1st week and the first month (p> 0.05). Creatinine levels decreased significantly on the third day compared to the first day. There was a significant positive correla- tion between B2 microglobulin and creatinine at postoperative day 0, day 3, day 7 and month 1 (p <0.05). Pentraxine and CRP levels increased signi- ficantly on the third day compared to the first day, then decreased significantly on the 7th day and the first month. (P <0.05) However, there was no significant correlation between pentraxin changes and CRP changes.

Conclusion: Early detection of inflammation in renal transplant recipients is important for the risk of graft rejection. B2 microglobu- lin and pentraxin levels may be used as new markers for graft rejec- tion and renal function evaluation, but randomized controlled trials with larger patient numbers are needed.

Keywords:: B2-microglobulin, inflammation, pentraxin, transplantation