Objectives: The aim of this study was to evaluate the outcomes of patients with adeno-carcinoma of the urinary bladder.
Materials and Methods: A total of 3590 patients with bladder tumors operated in our clinic between September 1998 and May 2013 were retrospectively evaluated. A total of 47 patients with adenocarcinoma, confirmed by histopathology, were included in this study. The patients’ characteristics, including age, gender, smoking history, tumor size, and localization, histological subtypes, pathological tumor sta-ges, treatment modalities and survival rates were all evaluated.
Results: The median age of the patients at diagnosis was 62 year (range; 19–81) and the male to female ratio was 4.9:1. The most common localization of tumor was left late-ral, trigone, right lateral, posterior, dome, and bladder neck, respectively. Most of the tumors (%78.8) were ≥3cm in size. Tumor growth pat-tern was adenocarcinoma not otherwise spe-cified (44.6%), mucinous (29.8%), signet-ring cell (12.8%), clear cell (4.3%) and mixed (8.5%). Twenty patients had undergone radical cystec-tomy and pelvic lymphadenectomy ± adjuvant treatment (chemotherapy/radiotherapy) and 21 patients received radiotherapy ± CT. The median survival time of patients with ade-nocarcinoma was 21 months (range 16-30).
Conclusions: Adenocarcinoma of the urinary bladder are ag-ressive tumors with low survival rates. The role of chemotherapy and radiotherapy in treatment is limited. Early radical cystectomy is a good treatment option for favorable prognosis.
Key Words: Adenocarcinoma, radical cystectomy, non-transitional cell carcinoma
Abstract
Objectives: The aim of this study was to evaluate the outcomes of patients with adeno-carcinoma of the urinary bladder.
Materials and Methods: A total of 3590 patients with bladder tumors operated in our clinic between September 1998 and May 2013 were retrospectively evaluated. A total of 47 patients with adenocarcinoma, confirmed by histopathology, were included in this study. The patients’ characteristics, including age, gender, smoking history, tumor size, and localization, histological subtypes, pathological tumor sta-ges, treatment modalities and survival rates were all evaluated.
Results: The median age of the patients at diagnosis was 62 year (range; 19–81) and the male to female ratio was 4.9:1. The most common localization of tumor was left late-ral, trigone, right lateral, posterior, dome, and bladder neck, respectively. Most of the tumors (%78.8) were ≥3cm in size. Tumor growth pat-tern was adenocarcinoma not otherwise spe-cified (44.6%), mucinous (29.8%), signet-ring cell (12.8%), clear cell (4.3%) and mixed (8.5%). Twenty patients had undergone radical cystec-tomy and pelvic lymphadenectomy ± adjuvant treatment (chemotherapy/radiotherapy) and 21 patients received radiotherapy ± CT. The median survival time of patients with ade-nocarcinoma was 21 months (range 16-30).
Conclusions: Adenocarcinoma of the urinary bladder are ag-ressive tumors with low survival rates. The role of chemotherapy and radiotherapy in treatment is limited. Early radical cystectomy is a good treatment option for favorable prognosis.
Key Words: Adenocarcinoma, radical cystectomy, non-transitional cell carcinoma