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Original Research

Diagnostic efficiency of miR-21 and miR-34a serum levels in malign and benign prostate diseases


1 Kulu State Hospital, Department of Medical Biochemistry, Konya, Turkey 2 Synevo Ataşehir Laboratory, Istanbul, Turkey
3 Hitit University, Erol Olçok Research and Training Hospital, Department of Urology, Corum, Turkey
4 Acıbadem LabGen Genetics Laboratory, Istanbul, Turkey
5 University of Health Sciences, Ankara City Hospital, Department of Urology, Ankara, Turkey
6 University of Health Sciences, Dışkapı Yıldırım Beyazıt Research and Training Hospital, Department of Medical Biochemistry, Ankara, Turkey
 


DOI : 10.33719/yud.2021;16-3-865045
New J Urol. 2021;16-(3): 221-227

ABSTRACT

Objective: To assess the factors affecting nocturia in young and older women with urinary incontinence (UI).

Material and Methods: Women who applied to the urology outpatient clinic with the UI complaint between November 2021-March 2022 were included. Demographic data, anthropometric measurements, medications and comorbidities were recorded. The ICIQ-SF test was applied to evaluate their quality of life. Patients who have been waking up at night with the need to urinate ≥2 were considered to have nocturia.

Results: Ninety-two women were included. Two groups were created as patients <60 years (n=47) and ≥60 years (n=45). The body mass index and waist circumference were higher in patients ≥60 years (respectively; p= 0.034, p= <0.001). Using of diuretic and anticholinergic medications was higher than in the younger group (respectively; p= <0.001, p= 0.006). The total number of medications was higher in the older group (p= <0.001). The number of comorbidities and the number of patients with Type 2 Diabetes Mellitus (DM) were higher in the older group (respectively; p= 0.002, p= 0.025). No difference was found in the young group with and without nocturia in terms of anthropometric measurements, medications used, and comorbidities. The number of medications and the number of Type 2 DM patients were significantly higher in the older group with nocturia (respectively; p= 0.04, p= 0.036).

Conclusion: Type 2 DM and multiple medication use are risk factors for nocturia in older women with UI. Evaluation and management of these risk factors may contribute to better clinical outcomes.

Keywords: aged, nocturia, risk factors, urinary incontinence, women


ABSTRACT

Objective: To assess the factors affecting nocturia in young and older women with urinary incontinence (UI).

Material and Methods: Women who applied to the urology outpatient clinic with the UI complaint between November 2021-March 2022 were included. Demographic data, anthropometric measurements, medications and comorbidities were recorded. The ICIQ-SF test was applied to evaluate their quality of life. Patients who have been waking up at night with the need to urinate ≥2 were considered to have nocturia.

Results: Ninety-two women were included. Two groups were created as patients <60 years (n=47) and ≥60 years (n=45). The body mass index and waist circumference were higher in patients ≥60 years (respectively; p= 0.034, p= <0.001). Using of diuretic and anticholinergic medications was higher than in the younger group (respectively; p= <0.001, p= 0.006). The total number of medications was higher in the older group (p= <0.001). The number of comorbidities and the number of patients with Type 2 Diabetes Mellitus (DM) were higher in the older group (respectively; p= 0.002, p= 0.025). No difference was found in the young group with and without nocturia in terms of anthropometric measurements, medications used, and comorbidities. The number of medications and the number of Type 2 DM patients were significantly higher in the older group with nocturia (respectively; p= 0.04, p= 0.036).

Conclusion: Type 2 DM and multiple medication use are risk factors for nocturia in older women with UI. Evaluation and management of these risk factors may contribute to better clinical outcomes.

Keywords: aged, nocturia, risk factors, urinary incontinence, women