Objective: In this study, our objective was to compare the preo-perative clinicopathological and radiographical findings of prosta-te cancer cases with gleason score 3+4 and 4+3 diagnosed by trans-rectal ultrasonography (TRUSG) guided biopsy.
Materials and Methods: A total of 1135 patients underwent 10-quadrant TRUSG guide prostate biopsy because of high PSA values or abnormal digital rectal examination in our clinic between 2004-2011. Of those patients who had adenocarcinoma were divi-ded into 2 groups of Gleason score 3+4 (Group 1, 56 patients) and Gleason score 4+3 (Group 2, 48 patients). These two groups were compared in terms of age, total PSA, PSA density, mean prostate size, positive core percentage, a positive core value of 33% or more, mean highest positive core tumor percentage, perineural invasion, rectal examination and tomography findings.
Results: Both groups are compared clinical, pathological and in terms of tomographical findings preoperatively. In this compari-son, there was no difference in terms of age, total PSA, PSA density; mean prostate volume, positive core percentage, a positive core va-lue of 33% or more, perineural invasion, rectal examination and to-mography findings. The mean highest positive core tumor percen-tage was %69.60 ± 25.31 in group 1 and %86.55 ±17.68 in group 2. The mean highest positive core tumor percentage was significantly higher in the group 2 (p<0,001).
Conclusion: Gleason score is one of the most important para-meters predicting postoperative prognosis in prostate adenocarci-noma cases. In this study we compared the cases of reported Glea-son score 3+4 and 4+3 on terms of preoperative clinicopathologic and radiography data, there was only a significant difference betwe-en mean highest positive core tumor percentage. This finding might explain worse prognosis in patients with gleason 4+3 but further studies and more clinical and pathological parameters are necessary to predict postoperative prognosis.
Key Words: Prostate cancer, Prostate biopsy, Gleason score
Abstract
Objective: In this study, our objective was to compare the preo-perative clinicopathological and radiographical findings of prosta-te cancer cases with gleason score 3+4 and 4+3 diagnosed by trans-rectal ultrasonography (TRUSG) guided biopsy.
Materials and Methods: A total of 1135 patients underwent 10-quadrant TRUSG guide prostate biopsy because of high PSA values or abnormal digital rectal examination in our clinic between 2004-2011. Of those patients who had adenocarcinoma were divi-ded into 2 groups of Gleason score 3+4 (Group 1, 56 patients) and Gleason score 4+3 (Group 2, 48 patients). These two groups were compared in terms of age, total PSA, PSA density, mean prostate size, positive core percentage, a positive core value of 33% or more, mean highest positive core tumor percentage, perineural invasion, rectal examination and tomography findings.
Results: Both groups are compared clinical, pathological and in terms of tomographical findings preoperatively. In this compari-son, there was no difference in terms of age, total PSA, PSA density; mean prostate volume, positive core percentage, a positive core va-lue of 33% or more, perineural invasion, rectal examination and to-mography findings. The mean highest positive core tumor percen-tage was %69.60 ± 25.31 in group 1 and %86.55 ±17.68 in group 2. The mean highest positive core tumor percentage was significantly higher in the group 2 (p<0,001).
Conclusion: Gleason score is one of the most important para-meters predicting postoperative prognosis in prostate adenocarci-noma cases. In this study we compared the cases of reported Glea-son score 3+4 and 4+3 on terms of preoperative clinicopathologic and radiography data, there was only a significant difference betwe-en mean highest positive core tumor percentage. This finding might explain worse prognosis in patients with gleason 4+3 but further studies and more clinical and pathological parameters are necessary to predict postoperative prognosis.
Key Words: Prostate cancer, Prostate biopsy, Gleason score