Investigation of Cyclin-D1 immunohistochemical expression in bladder urethelial carcinoma

ABSTRACT

Objective: Hematuria is defined as the presence of red blood cells in urine, which may be observed microscopically or grossly. Hematuria may originate from any site throughout the urinary tract, glomerulus, interstitium, or the renal vasculature. Here, we present the case of a 17-year-old boy who developed terminal hematuria after two months of treatment with isotretinoin for acne vulgaris. Radiological and cystoscopic assessment of the urinary system were normal. Isotretinoin treatment was discontinued after dermatology consultation. After two weeks, terminal hematuria disappeared along with dysuria, and the urine sample showed normal findings. 

Keywords: Acne vulgaris, adverse effect, gross hematuria, isotretinoin 

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ABSTRACT

Objective: Hematuria is defined as the presence of red blood cells in urine, which may be observed microscopically or grossly. Hematuria may originate from any site throughout the urinary tract, glomerulus, interstitium, or the renal vasculature. Here, we present the case of a 17-year-old boy who developed terminal hematuria after two months of treatment with isotretinoin for acne vulgaris. Radiological and cystoscopic assessment of the urinary system were normal. Isotretinoin treatment was discontinued after dermatology consultation. After two weeks, terminal hematuria disappeared along with dysuria, and the urine sample showed normal findings. 

Keywords: Acne vulgaris, adverse effect, gross hematuria, isotretinoin 

Resources

• 1.C. G. Pan. “Evaluation of Gross Hematuria,” Pediatr. Clin. North Am., vol. 53, no. 3, pp. 401-412, Jun. 2006.
  PUBMED CROSSREF
• 2.B. Forouzani-Haghighi and I. Karimzadeh. “Isotretinoin and the Kidney: Opportunities and Threats.,” Clin. Cosmet. Investig. Dermatol., vol. 13, pp. 485-494, 2020.
  PUBMED CROSSREF
• 3.E. Sarifakioglu, A. E. Yilmaz, S. Erpolat. “Terminal hematuria associated with oral isotretinoin treatment in a patient with acne vulgaris.,” Pediatr. Dermatol., vol. 29, no. 5, pp. 668-669, 2012.
  PUBMED CROSSREF
• 4.J. Tan, S. Boyal, K. Desai, S. Knezevic. “Oral Isotretinoin: New Developments Relevant to Clinical Practice.,” Dermatol. Clin., vol. 34, no. 2, pp. 175-184, Apr. 2016.
  PUBMED CROSSREF
• 5.B. Yesilkaya, N. Alli, R. F. Artuz, E. Ulu, D. Kartal, S. L. Cinar. “The frequency of hematuria in acne vulgaris patients during isotretinoin treatment.,” Cutan. Ocul. Toxicol., vol. 36, no. 1, pp. 74-76, Mar. 2017.
  PUBMED CROSSREF