Objectives: Limited data exist regarding the comparison of 6, 8, 10 and 12 cores of tran-srectal ultrasound guided biopsy (TRUS-Bx) of the prostate in detecting prostate cancer (PCa). The purpose of this study was to compare the cancer detection rates of 6, 8, 10 and 12 cores TRUS-Bx of the prostate on the same cohort of patients.
Material and Methods: Between February 2005 and January 2011, 2033 men with serum PSA levels higher than 2.5 ng/mL and/or with an abnormal digital rectal examination under-went TRUS-Bx of the prostate. Of the patients, 1131 (55.6%) who underwent initial 12 cores TRUS-Bx of the prostate were included in the study. Patients’ pathology results were re-evalu-ated if they had undergone 6, 8, and 10 cores bi-opsies rather than 12 cores. PCa detection rates of these techniques were compared.
Results: Overall, 20.9% (236 of 1131) of the patients had PCa detected on 12 cores biopsy. Cancer detection rates of 6 cores, 8 cores and 10 cores biopsies were calculated as 16.4%, 20.1% and 20.4%, respectively. No significant dif-ference was detected between 10 and 12 cores biopsy techniques in detecting PCa (P = 0.06). However, 12 cores biopsy had significantly higher PCa detection rate compared to both 6 (P < 0.0001) and 8 (P = 0.0039) cores biopsies.
Conclusion: Standard 6 and 8 cores of prostate biopsy seem to be inferior compared to 10 or 12 cores of TRUS-Bx of the prostate in detecting PCa. Therefore, 12 cores should be included in the initial TRUS-Bx of the prostate.
Keywords: Biopsy, prostate, prostate neo-plasm
Abstract
Objectives: Limited data exist regarding the comparison of 6, 8, 10 and 12 cores of tran-srectal ultrasound guided biopsy (TRUS-Bx) of the prostate in detecting prostate cancer (PCa). The purpose of this study was to compare the cancer detection rates of 6, 8, 10 and 12 cores TRUS-Bx of the prostate on the same cohort of patients.
Material and Methods: Between February 2005 and January 2011, 2033 men with serum PSA levels higher than 2.5 ng/mL and/or with an abnormal digital rectal examination under-went TRUS-Bx of the prostate. Of the patients, 1131 (55.6%) who underwent initial 12 cores TRUS-Bx of the prostate were included in the study. Patients’ pathology results were re-evalu-ated if they had undergone 6, 8, and 10 cores bi-opsies rather than 12 cores. PCa detection rates of these techniques were compared.
Results: Overall, 20.9% (236 of 1131) of the patients had PCa detected on 12 cores biopsy. Cancer detection rates of 6 cores, 8 cores and 10 cores biopsies were calculated as 16.4%, 20.1% and 20.4%, respectively. No significant dif-ference was detected between 10 and 12 cores biopsy techniques in detecting PCa (P = 0.06). However, 12 cores biopsy had significantly higher PCa detection rate compared to both 6 (P < 0.0001) and 8 (P = 0.0039) cores biopsies.
Conclusion: Standard 6 and 8 cores of prostate biopsy seem to be inferior compared to 10 or 12 cores of TRUS-Bx of the prostate in detecting PCa. Therefore, 12 cores should be included in the initial TRUS-Bx of the prostate.
Keywords: Biopsy, prostate, prostate neo-plasm