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Intravenous paracetamol versus oral tramadol for pain control during shockwave lithotripsy: a prospective randomized comparative study


1 Department of Urology, BozyakaTraining and Research Hospital, Izmir, Turkey

2 Department of Urology, Acibadem University, School of Medicine, Istanbul, Turkey

3 Department of Anesthesiology, Pamukkale University, School of Medicine, Denizli, Turkey

4 Department of Anesthesiology, Kutahya Kent Hospital, Kutahya, Turkey

5 Department of Urology, Pamukkale University, School of Medicine, Denizli, Turkey


DOI :
New J Urol. 2016; 11 (1): 14-21
Abstract

Abstract

Objectives: Shock wave lithotripsy (SWL) is a simple, effective, and minimally invazive treatment option for urinary tract stone disease. Nevertheless, pain during the SWL procedure is one of the most common restriction factor for this treatment modality.We aimed to compare the efficacy and adverse effects of intravenous (IV) paracetamol and oral (tablet) tramadol for pain control during SWL procedure.

Material and Methods: We enrolled 54 patients with the indication of SWL therapy in this prospective randomized comparative study. 1 g IV paracetamol infusion was applied to group I (n:28) and 100 mg oral tramadol was applied to group II ( n:26). The pain was mea-sured by 10-point visual analog scale (VAS). 1 mg/kg of body weight intramuscular pethidine (meperidine) was applied when supplemental analgesia required.

Results: The mean VAS score was signifi-cantly lower in group I patients than in group II at 5, 10, 15, 30, 40th minutes during lithotripsy (P=0.011, P=0.009, P=0.001, P=0.000, P=0.000, respectively). Supplementary analgesic require-ment was higher in group I than group II which received more shockwaves or higher voltages. However, this difference was not statistically significant (P=0.199).

Conclusions: This is the first study com-paring the analgesic effects of IV paracetamol

Abstract

Objectives: Shock wave lithotripsy (SWL) is a simple, effective, and minimally invazive treatment option for urinary tract stone disease. Nevertheless, pain during the SWL procedure is one of the most common restriction factor for this treatment modality.We aimed to compare the efficacy and adverse effects of intravenous (IV) paracetamol and oral (tablet) tramadol for pain control during SWL procedure.

Material and Methods: We enrolled 54 patients with the indication of SWL therapy in this prospective randomized comparative study. 1 g IV paracetamol infusion was applied to group I (n:28) and 100 mg oral tramadol was applied to group II ( n:26). The pain was mea-sured by 10-point visual analog scale (VAS). 1 mg/kg of body weight intramuscular pethidine (meperidine) was applied when supplemental analgesia required.

Results: The mean VAS score was signifi-cantly lower in group I patients than in group II at 5, 10, 15, 30, 40th minutes during lithotripsy (P=0.011, P=0.009, P=0.001, P=0.000, P=0.000, respectively). Supplementary analgesic require-ment was higher in group I than group II which received more shockwaves or higher voltages. However, this difference was not statistically significant (P=0.199).

Conclusions: This is the first study com-paring the analgesic effects of IV paracetamol

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