Norepinephrine infusion in brain dead organ donor: A retrospective study on its effects on graft function after renal transplant

ABSTRACT

Objective: To investigate the effect of vasoactive drugs use in brain-dead organ donors in renal recipient graft function.

Material and Methods: Clinical data from 30 brain-dead organ donors, and 30 recipients in our center were analyzed retrospectively between July 2017 and November 2021.

Results: Norepinephrine infusion was used in all 30 cadaveric donors, where 11 donors had inotropic combinations. Norepinephrine was infused at a median dose of 0.2mcg/kg/min. There was no relationship between duration and doses of norepinephrine in donors and graft rejection, graft  loss, and dialysis requirement in renal recipients.

Conclusion: Intravenous norepinephrine infusion below 0.2mcg/kg/min had no effect on graft function in the renal recipient, where fluid resuscitation was sufficient in the cadaveric donor.

Keywords: Brain dead, organ donors, vasoactive drugs, graft survival.

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ABSTRACT

Objective: To investigate the effect of vasoactive drugs use in brain-dead organ donors in renal recipient graft function.

Material and Methods: Clinical data from 30 brain-dead organ donors, and 30 recipients in our center were analyzed retrospectively between July 2017 and November 2021.

Results: Norepinephrine infusion was used in all 30 cadaveric donors, where 11 donors had inotropic combinations. Norepinephrine was infused at a median dose of 0.2mcg/kg/min. There was no relationship between duration and doses of norepinephrine in donors and graft rejection, graft  loss, and dialysis requirement in renal recipients.

Conclusion: Intravenous norepinephrine infusion below 0.2mcg/kg/min had no effect on graft function in the renal recipient, where fluid resuscitation was sufficient in the cadaveric donor.

Keywords: Brain dead, organ donors, vasoactive drugs, graft survival.

Resources

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