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Original Research

Which prostate spesific antigen level is important?


Bozok Üniversitesi Tıp Fakültesi, Üroloji Ana Bilim Dalı, Yozgat


DOI :
New J Urol. 2014; 9 (3): 38-43

Abstract

Objectives: To explore the association of perineural invasion with tumor positive cores and tumor volume in TRUS biopsy.

Material and Methods: 85 patients, diag-nosed with prostate adenocarcinoma via TRUS biopsy were evaluated. Of any observed perine-ural invasion in any core for each patient was reported as “PNI(+)”. Also the amount of tu-mor in the each core was reported by percen-tage. Patients were divided into two groups due to their pathology reports which were PNI(+) or PNI(-). Age, PSA, prostate volume, Gleason score, number of biopsy cores, the number of cancer-positive cores, cancer-positive core lo-calizations, percentage of tumor in each core findings were compared statistically between two groups.

Results: Of patients 42(49,4%) were PNI(+) and 43(50,6%) were PNI(-).Median PSA, glea-son score and number of tumor positive cores were significantly higher in PNI(+) group. Also the percentage of tumor in each core was sig-nificantly higher in PNI(+) group (p:0.00), ex-cept transition zone (P:0.217).  Approximately, tumor percentage in PNI(+) group was 4 fold of PNI(-) was. By the association between PNI and tumor positivity in the cores; tumor was being higher in whole cores in PNI(+) group then the other, except transition zone.

Conclusion: It was presented quantitatively in our study that number of tumor positive biopsy cores and the percentage of tumor in that cores were signifi-cantly higher in PNI(+) group. We suppose that these findings are to be carried hints to guide treatment and surgical methods.

Key Words: Prostate cancer, perineural invasion, tumor volume


Abstract

Objectives: To explore the association of perineural invasion with tumor positive cores and tumor volume in TRUS biopsy.

Material and Methods: 85 patients, diag-nosed with prostate adenocarcinoma via TRUS biopsy were evaluated. Of any observed perine-ural invasion in any core for each patient was reported as “PNI(+)”. Also the amount of tu-mor in the each core was reported by percen-tage. Patients were divided into two groups due to their pathology reports which were PNI(+) or PNI(-). Age, PSA, prostate volume, Gleason score, number of biopsy cores, the number of cancer-positive cores, cancer-positive core lo-calizations, percentage of tumor in each core findings were compared statistically between two groups.

Results: Of patients 42(49,4%) were PNI(+) and 43(50,6%) were PNI(-).Median PSA, glea-son score and number of tumor positive cores were significantly higher in PNI(+) group. Also the percentage of tumor in each core was sig-nificantly higher in PNI(+) group (p:0.00), ex-cept transition zone (P:0.217).  Approximately, tumor percentage in PNI(+) group was 4 fold of PNI(-) was. By the association between PNI and tumor positivity in the cores; tumor was being higher in whole cores in PNI(+) group then the other, except transition zone.

Conclusion: It was presented quantitatively in our study that number of tumor positive biopsy cores and the percentage of tumor in that cores were signifi-cantly higher in PNI(+) group. We suppose that these findings are to be carried hints to guide treatment and surgical methods.

Key Words: Prostate cancer, perineural invasion, tumor volume