Objective: Our study aimed to assess the rela-tionship between lymphovascular invasion (LVI) on transurethral resection of bladder carcinoma (TURB) pathology and disease progression, recur-rence and development of metastasis in patients with T1 bladder cancers.
Material and Methods: The clinical records of patients having undergone TURB in our clinic were retrospectively reviewed. Newly diagnosed pT1 patients with urothelial bladder cancer were included in the study. Of the patients; sex, age, initial diagnosis or recurrence, tumor size, tumor number, grade, presence of Cis, presence of in-travesical treatment, follow up times, recurrence, progression, metastasis and lymphovascular inva-sion were recorded. Patients were divided into two groups according to LVI status and compared in terms of recurrence, progression and metastasis.
Results: Ninety three patients with pT1 uro-thelial bladder cancer were enrolled. The mean age of the patients was 63.96 ± 9.94 (36-84). The mean tumor size was 4.29 ± 2.54 cm (1-10 cm) and the mean number of tumors was 2.46 ± 1.48 (1-5). LVI was detected in 27 patients (29%). Of the 51 pa-tients with recurrence, 18 had LVI and 33 had no LVI (p> 0.05). Of the 22 patients with progression, 14 had LVI and 8 had no LVI (p <0.01). Of the 15 patients with metastasis, 11 had LVI and 4 had no LVI (p <0.01).
Conclusion: In the patients with T1 baldder cancer, LVI after TURB is associated with the pro-gression and metastasis of disease. Therefore, it is a prognostic factor that can be used when plan-ning the follow-up and treatment of the disease. When planning the treatment of patients with su-perficial bladder tumors with LVI, we think that they should be more careful and aggressive than non-LVI patients.
Keywords: Bladder cancer, Lymphovascular invasion, Prognosis, Transurethral resection of bladder tumor
Abstract
Objective: Our study aimed to assess the rela-tionship between lymphovascular invasion (LVI) on transurethral resection of bladder carcinoma (TURB) pathology and disease progression, recur-rence and development of metastasis in patients with T1 bladder cancers.
Material and Methods: The clinical records of patients having undergone TURB in our clinic were retrospectively reviewed. Newly diagnosed pT1 patients with urothelial bladder cancer were included in the study. Of the patients; sex, age, initial diagnosis or recurrence, tumor size, tumor number, grade, presence of Cis, presence of in-travesical treatment, follow up times, recurrence, progression, metastasis and lymphovascular inva-sion were recorded. Patients were divided into two groups according to LVI status and compared in terms of recurrence, progression and metastasis.
Results: Ninety three patients with pT1 uro-thelial bladder cancer were enrolled. The mean age of the patients was 63.96 ± 9.94 (36-84). The mean tumor size was 4.29 ± 2.54 cm (1-10 cm) and the mean number of tumors was 2.46 ± 1.48 (1-5). LVI was detected in 27 patients (29%). Of the 51 pa-tients with recurrence, 18 had LVI and 33 had no LVI (p> 0.05). Of the 22 patients with progression, 14 had LVI and 8 had no LVI (p <0.01). Of the 15 patients with metastasis, 11 had LVI and 4 had no LVI (p <0.01).
Conclusion: In the patients with T1 baldder cancer, LVI after TURB is associated with the pro-gression and metastasis of disease. Therefore, it is a prognostic factor that can be used when plan-ning the follow-up and treatment of the disease. When planning the treatment of patients with su-perficial bladder tumors with LVI, we think that they should be more careful and aggressive than non-LVI patients.
Keywords: Bladder cancer, Lymphovascular invasion, Prognosis, Transurethral resection of bladder tumor