Objective: In this study, we aimed to evaluate the effect of the transurethral resection of the prostate on PSA, f/t PSA ratio, PSAD and the usefulness of these markers for cancer detection after the operation in patients who had 2.5-10 ng/mL PSA level..
Materials and Methods: A total of 50 patients who underwent TUR-P in our clinic were evaluated. Patients who had PSA levels between 2,5-10 ng/mL with benign pathology after needle biopsies and the age between 50-70 were included in the study. Blood PSA level, f/tPSA ratio and PSA density were calculated in preoperative period, postoperative third and sixth months. The resected prostate volumes were calculated from the difference between preoperative and postoperative third month prostate volumes. In this way the mean PSA, mean f/t PSA ratio and mean PSAD between preoperative, postoperative third and sixth month were compared.
Results: Mean age value was 61,82 ± 4,11 (53-69 years). Postoperative 3. month PSA and PSAD levels were lower than preoperative PSA and PSAD levels and it was statistically significant (p=0,041, p 0,001). But there was no significant difference between postoperative third and sixth month for PSA and PSAD levels (p=0,348, p=0,550). On the other hand there was no significant difference between preoperative, postoperative third and sixth month f/ tPSA ratio (p=0,954; p=0,200).
Conclusion: The usefulness of the markerssuch as PSA and PSAD for prostate cancer detection is limited because of low levels in postoperative period. On the other hand, because of there is no change in f/tPSA ratio, this ratio can be used as a marker of cancer detection in this new population.
Key Words: BPH, PSA, TUR-P, PSAD, f/t PSA
Abstract
Objective: In this study, we aimed to evaluate the effect of the transurethral resection of the prostate on PSA, f/t PSA ratio, PSAD and the usefulness of these markers for cancer detection after the operation in patients who had 2.5-10 ng/mL PSA level..
Materials and Methods: A total of 50 patients who underwent TUR-P in our clinic were evaluated. Patients who had PSA levels between 2,5-10 ng/mL with benign pathology after needle biopsies and the age between 50-70 were included in the study. Blood PSA level, f/tPSA ratio and PSA density were calculated in preoperative period, postoperative third and sixth months. The resected prostate volumes were calculated from the difference between preoperative and postoperative third month prostate volumes. In this way the mean PSA, mean f/t PSA ratio and mean PSAD between preoperative, postoperative third and sixth month were compared.
Results: Mean age value was 61,82 ± 4,11 (53-69 years). Postoperative 3. month PSA and PSAD levels were lower than preoperative PSA and PSAD levels and it was statistically significant (p=0,041, p 0,001). But there was no significant difference between postoperative third and sixth month for PSA and PSAD levels (p=0,348, p=0,550). On the other hand there was no significant difference between preoperative, postoperative third and sixth month f/ tPSA ratio (p=0,954; p=0,200).
Conclusion: The usefulness of the markerssuch as PSA and PSAD for prostate cancer detection is limited because of low levels in postoperative period. On the other hand, because of there is no change in f/tPSA ratio, this ratio can be used as a marker of cancer detection in this new population.
Key Words: BPH, PSA, TUR-P, PSAD, f/t PSA