Objective: In this study, we aimed to evaluate the relationship between biochemical recurrence time and the “cancer of the prostate risk assessment post-surgery” score (CAPRA-S) after radical pros- tatectomy (RP).
Material and Methods: Retrospective evalu- ation was made of the records of 328 patients ap- plied with RP for a diagnosis of clinically localized prostate cancer. The patients were separated into groups according to the CAPRA-S score deter- mined according to the preoperative PSA level and pathological characteristics of the RP specimen and the biochemical recurrence time after RP.
Results: The mean follow-up period was 76.9±34.5 months. Biochemical recurrence was determined in 23.2% (n:69) of the cases, as early recurrence in 71% (n:49) and late in 29% (n:20). According to the CAPRA-S score, 186 (62.4%) patients were classified as low risk, 66 (22.1%) as moderate risk, and 46 (15%) as high risk. The 3 and 5-year BRFS rates of all the patients were 88.9% and 81.8% respectively. Patients with a low CAPRA-S score were determined to have a statis- tically significantly higher 3 and 5-year BRFS rate than patients in the moderate and high groups. Early biochemical recurrence after RP was statisti- cally significantly correlated only with lymph node involvement (OR: 2.42, 95% CI: 1.07-5.47, p=0.03).
Conclusion: This study showed that the CAPRA-S score, which is effective in predicting the risk of biochemical recurrence after RP, was not effective in predicting the time of biochemical recurrence after RP.
Keywords: Biochemical recurrence, CAPRA-S score, prostate cancer, radical prostatectomy
ABSTRACT
Objective: In this study, we aimed to evaluate the relationship between biochemical recurrence time and the “cancer of the prostate risk assessment post-surgery” score (CAPRA-S) after radical pros- tatectomy (RP).
Material and Methods: Retrospective evalu- ation was made of the records of 328 patients ap- plied with RP for a diagnosis of clinically localized prostate cancer. The patients were separated into groups according to the CAPRA-S score deter- mined according to the preoperative PSA level and pathological characteristics of the RP specimen and the biochemical recurrence time after RP.
Results: The mean follow-up period was 76.9±34.5 months. Biochemical recurrence was determined in 23.2% (n:69) of the cases, as early recurrence in 71% (n:49) and late in 29% (n:20). According to the CAPRA-S score, 186 (62.4%) patients were classified as low risk, 66 (22.1%) as moderate risk, and 46 (15%) as high risk. The 3 and 5-year BRFS rates of all the patients were 88.9% and 81.8% respectively. Patients with a low CAPRA-S score were determined to have a statis- tically significantly higher 3 and 5-year BRFS rate than patients in the moderate and high groups. Early biochemical recurrence after RP was statisti- cally significantly correlated only with lymph node involvement (OR: 2.42, 95% CI: 1.07-5.47, p=0.03).
Conclusion: This study showed that the CAPRA-S score, which is effective in predicting the risk of biochemical recurrence after RP, was not effective in predicting the time of biochemical recurrence after RP.
Keywords: Biochemical recurrence, CAPRA-S score, prostate cancer, radical prostatectomy